TC Callahan, an ex-Army medic, works the night shift at a San Antonio hospital where several other former military personnel are on staff. Jordan Alexander, TC's one-time girlfriend, has just been promoted to shift leader. TC performs a field surgery to save a car accident victim, as astonished paramedics look on. At the hospital, TC wants to operate on the uninsured victim, but Michael Ragosa, the head of administration, wants the man transported elsewhere.
TC's gambling habit seems strong, as Topher spots him in the Tailgate inflatable pool, placing several bets. He already owes Topher $800 from the last failed bets. Drew reads email from his boyfriend still deployed overseas, but quickly shuts it down when others approach. TC struggles with the idea of losing Nick, a close friend whose life was saved because TC gave permission for his dying brother's heart to be transplanted to him.
While fighting in the tailgate area, Drew hurts his hand and tries to hide it from Jordan during his shift. Ragosa announces that the tailgate must be shut down, citing legal and safety reasons. TC and Paul remove a man and a woman from a wild, drunken hog hunt via MedEvac.
On Jordan's birthday, her long-distance boyfriend, Scott, cannot visit her. Drew is at a training mission. Paul, wanting to watch Topher do a surgical procedure, dismisses a female patient's stomach pain as the flu and puts off reading her EKG results. Jordan spots TC holding Landry's hand after discussing a patient. Ragosa accidentally takes ecstasy, thinking it was aspirin.
A storm hits San Antonio, causing a blackout. Paul attends to a kid whose mother is injured in the storm. Landry feels that TC and Jordan still have feelings that they need to work out. Meanwhile, Scott plans to stay at the hospital as head of the trauma department. Krista helps Drew deal with a nurse offering her niece as a date.
Rick and his platoon are riding a bus into San Antonio when their bus is in an accident. TC goes to Jordan's home to talk about their kiss. Private Wilson, a member of Rick's platoon, flirts with Krista, who eventually agrees to a date. Ragosa posts an internet dating profile with help from Kenny. Landry deals with a mentally unstable woman who is convinced she is carrying Matt Damon's baby.
TC and Topher are dropped from a helicopter to a small plane crash site, where they find the pilot dead and the only other passenger suffering from a severely crushed chest. Paul takes care of a stripper who fell off a pole on the job and suffered a seemingly minor injury. Krista treats a teenage girl named Nina. Jordan is drawn in and the doctors desperately try to keep their patient alive, despite not being able to get him to a proper operating room.